The Vitamin D Receptor

The vitamin D receptor (VDR) is a nuclear transcription factor that is turned on by the presence of calcitriol. It forms a heterodimer with retinoid X after which enters the nucleus where it binds to specific DNA sequences called Vitamin D responsive factors.

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In mammals, the VDR plays a pivotal role in the locks cycle, and loss of the receptor is usually associated with thinning hair. It is important for the induction of postnatal scalp cycle paths and for the regulation of postmorphogenic hair cycle paths. The VDR is indicated in the intestinal tract, the thyroid, the kidney, and in numerous types of defense cells.

Many myeloid leukemia cell lines express the VDR, although at diverse levels. In a study of HL-60 cellular material, a substance called 1, 25(OH)2D3 (10-7 M) decreased the VDR protein level simply by 50% inside 24 hours. Following 72 several hours, VDR proteins levels returned to normalcy. However , the drug would not affect the degree of VDR mRNA or necessary protein expression.

Although VDR is usually expressed for most neurons, it is also found in glial cells and a subset of person primary glioblastoma cellular material. The proteins has been immunoreactive in oligodendrocytes of the white matter. Furthermore, VDR has been recognized in glial fibrillary acid protein.